Our five year old black lab has early onset Osteo arthritis. She loves to run, but all four of her legs took turns hurting. A friend suggested DPA. She is 200 lbs. so we give her four chews per day. For the first time, in a long time, she is playing and running around again!. It took about two weeks to see the extent of how much it is helping her. Our Vet wrote down the name of this product and is going to mention it to other patients